The Buffalo Bills defeated the San Francisco 49ers 35-10 on a snowy Sunday night to clinch their fifth straight AFC East crown. Buffalo is the first team to clinch a division this season and the earliest (5 weeks remaining) to do so since the 2009 Indianapolis Colts. With the Bills’ seventh consecutive win and sixth straight game at 30+ points, Sean McDermott is now 8-0 coming off a bye week in his career.

The Bills are fresh off the bye week and welcome the reigning NFC Champion San Francisco 49ers to Highmark Stadium for Sunday Night Football. Buffalo is 7-0 off the bye since Sean McDermott became the head coach and is facing a desperate 49ers team that has lost its last two games. Brock Purdy returns to the lineup but San Francisco will be missing some key players on both sides of the ball. The Buffalo will be without Dalton Kincaid but All-Pro LB Matt Milano is expected to make his return to the field.