The Bills welcome Trevor Lawrence and the Jacksonville Jaguars to Highmark Stadium. Former Bills Gabe Davis and Mitch Morse make their return on a Monday Night Football Double Header.

Matchup to Watch: Josh Hines-Allen vs Dion Dawkins

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The Bills head to Baltimore to face Lamar Jackson and the Ravens on Sunday Night Football.

Matchup to Watch: Lamar Jackson vs Bills LBs

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The Bills head to Houston for the highly anticipated matchup with Stefon Diggs and the C.J. Stroud-led Texans.

Matchup to Watch: Stefon Diggs vs Taron Johnson

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The Bills head to New Jersey for a Monday Night matchup with Aaron Rodgers and the Jets.

Matchup to Watch: Greg Rousseau vs Morgan Moses

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The Bills return home after three road games for a matchup with Will Levis and the Titans at Highmark Stadium.

Matchup to Watch: Jeffery Simmons vs Bills IOL

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The Bills head to the Pacific Northwest for the first time since 2016 to face Geno Smith and the Seahawks.

Matchup to Watch: Kenneth Walker III vs Bills DL

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The Bills welcome the high-flying offense of the Tua Tagovailoa-led Dolphins to Highmark Stadium for a 1 PM affair.

Matchup to Watch: Tyreek Hill vs Bills DBs

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Teams have until 4 PM to execute any trades.

The Bills head to Indianapolis for a matchup with Anthony Richardson and the Colts.

Matchup to Watch: Jonathan Taylor vs Bills DL

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The Bills play host to Patrick Mahomes and the reigning Super Bowl Champion Chiefs. Bills Mafia looks to head into the bye week flying high, sending the Chiefs back to Kansas City and having to Shake it Off.

Matchup to Watch: Chris Jones vs Bills OL

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The Bills are 7-0 coming off their bye week under Sean McDermott.

The Bills host the reigning NFC Champion San Francisco 49ers in primetime on Sunday Night Football.

Matchup to Watch: Christian McCaffrey vs Bills LBs

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The Bills continue their NFC West matchups, heading to L.A. to face Matthew Stafford and the Rams. This will be the first matchup vs. former Bill Tre’Davious White

Matchup to Watch: Dalton Kincaid vs Rams LBs

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The Bills head to the Motor City for their last 4:25 kickoff of the season vs Jared Goff and the Lions.

Matchup to Watch: Amon-Ra St. Brown vs Taron Johnson

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The Bills welcome rookie Drake Maye and the Patriots to Buffalo for their first of two matchups in three weeks.

Matchup to Watch: Bills DL vs Patriots OL

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The Bills welcome Aaron Rodgers and the division rival Jets to New York.

Matchup to Watch: Sauce Gardner vs Khalil Shakir

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The Bills head to Foxboro for their final game of the season vs Drake Maye and the Patriots.

Matchup to Watch: Terrel Bernard vs Hunter Henry