The Bills welcome rookie Drake Maye and the Patriots to Buffalo for their first of two matchups in three weeks.

Matchup to Watch: Ed Oliver and Greg Rousseau vs Patriots OL

Airing on CBS: Bills -14 o/u 46.5

The Bills head to the Motor City for their last 4:25 kickoff of the season vs Jared Goff and the Lions.

Matchup to Watch: Amon-Ra St. Brown vs Taron Johnson

Airing on CBS: Lions -2.5 o/u 54.5

The Bills continue their NFC West matchups, heading to L.A. to face Matthew Stafford and the Rams. Will Buffalo make it 8 wins in a row?

Matchup to Watch: Rams Pass Rush vs Bills OL

Airing on Fox: Bills -3.5 o/u 49.5

The Bills host the reigning NFC Champion San Francisco 49ers in primetime on Sunday Night Football.

Matchup to Watch: Christian McCaffrey vs Bills LBs

Airing on NBC: Bills -6 o/u 44.5

The Bills are 7-0 coming off their bye week under Sean McDermott.

The Bills play host to Patrick Mahomes and the reigning Super Bowl Champion Chiefs. Bills Mafia looks to head into the bye week flying high, sending the Chiefs back to Kansas City and having to Shake it Off.

Matchup to Watch: Chris Jones vs Bills OL

Airing on CBS: Bills -2 45.5

The Bills head to Indianapolis for a matchup with Joe Flacco and the Colts.

Matchup to Watch: Jonathan Taylor vs Bills Front 7

Airing on CBS: Bills -4 o/u 46.5

Teams have until 4 PM to execute any trades.

The Bills welcome their AFC East rivals, the Tua Tagovailoa-led Miami Dolphins, to blustery Highmark Stadium for their last game before the trade deadline.

Matchup to Watch: Josh Allen vs Miami Defense

Airing on CBS: Bills -6.5 o/u 49.5

The Bills head to the Pacific Northwest for the first time since 2016 to face Geno Smith and the Seahawks.

Matchup to Watch: Kenneth Walker III vs Bills DL

Airing on Fox Bills -3 o/u 48.5

The Bills return home after three road games to face Will Levis and the Titans at Highmark Stadium. The Bills will be looking to build off their Monday Night victory over the Jets and welcome new WR Amari Cooper to Bills Mafia.

Matchup to Watch: Jeffery Simmons vs Bills IOL

Airing on CBS: Buffalo -9 o/u 40.5

The 3-2 Bills head to New Jersey for a Monday Night matchup with Aaron Rodgers and the 2-3 Jets. Both teams will be looking to end their two-game losing streaks, with the winner taking over first place in the AFC East.

Matchup to Watch: Bills OL vs Jets DL

Airing on ESPN Bills -1 o/u 41.5

The Bills head to Houston for the highly anticipated matchup with Stefon Diggs and the C.J. Stroud-led Texans.

Matchups to Watch: Nico Collins and Stefon Diggs vs Bills DBs

Airing on CBS Texans -1 o/u 47.5

The Bills head to Baltimore to face Lamar Jackson and the Ravens on Sunday Night Football.

Matchup to Watch: Lamar Jackson vs Bills LBs

Airing on NBC BAL -2.5 o/u 46.5

The Bills welcome Trevor Lawrence and the Jacksonville Jaguars to Highmark Stadium. Former Bills Gabe Davis and Mitch Morse make their return on a Monday Night Football Double Header.

Matchup to Watch: Josh Hines-Allen vs Dion Dawkins

Airing on ESPN Bills -5 o/u 46.5

Division rivals face off for their first matchup of the season as the Bills head to Miami to take on Tua Tagovailoa and the Dolphins on Thursday Night Football

Matchup to watch: Greg Rousseau vs Austin Jackson

Airing on Amazon Prime Video Dolphins -2.5 o/u 48.5

The Bills open the 2024 season at home versus Kyler Murray and the Arizona Cardinals.

Matchup to watch: Marvin Harrison Jr. vs Bills DBs

Airing on CBS, Bills -6.5 o/u 48.5

NFL rosters must be at 53 men by 4 PM on August 27th.

The Bills welcome the Carolina Panthers for their final preseason matchup. Injuries have struck the Bills hard of late and Sean McDermott announced that there will be no starters playing Saturday.